You asked about experience with towing with 2500 2 wheel drive.
I have been towing for over 20 years and over 180,000 miles (4 different fifth wheels) all with 2500 2 rear wheel drive. The last several trucks have been diesel but we started out with gasoline.
In all these 20+ years I can only remember one time when 4 wheel drive would have made any difference. After a sudden rain in Florida many years ago the ground became slippery. Within minutes a park ranger had come to help us out. That's it. Not one other time we could have used four wheel drive.
