Are they hard to maneuver, park, drive, navigating gas stations etc?
I guess that's a relative term. The longer they are the more you have to be careful when turning.
How are grades navigated?
No difference there, just try to get enough truck. I usually need to downshift.
what's set up like?
They are more work than a MH, for sure. The part I don't like is leveling, but newer coaches come with levelers.
How hard is it to break camp and travel?
I wouldn't say it's hard, just more time consuming.
DW worries about them flipping over and taking the truck with it in an accident, wind or uneven terrain. is that risk real?
I suppose anything is possible in a crash. Wind? I've been in Lake Mead wind with my 34' coach. Scared out of my mind, but nothing happened. Fivers are not something you want to be pulling into ATV territory.