Yes, been doing this for 15 years. No issues. Braking is no trouble. Yes on the steeper grades you will be hanging out with the loaded semis big deal. Been over the Rockies, through Death Valley, Yellowstone, west coast, Glacier, Grand Canyon, Carlsbad Caverns, would not hesitate to go about anywhere. Very stable in all conditions. Has never felt unsafe. Truck has just over 200,000 miles and still does great. No maintenance issues. Original transmission. New 400hp vs my tired 260hp would make pulling a breeze.
Can't say it is for everyone but I am very happy.