The pivot head on the hitch will probably adjust to the angle ok. The issue may be about how much bed rail to the underside of the 5er clearance you have. Some new trucks sit real high. If the 5er is sitting low there may be interference. That brings up another issue which is how high your truck is to the 5er even when it's on level ground. Some 5er and TT require spring/axle flips or other tricks to raise them to level with the truck. You need to look into all that as you consider what to buy. High truck/low 5er = modifications.
If you use an auto slider hitch like Pullrite, the 5er will need a capture plate. Because of the capture plate "key" type area that has to match up with the hitch plate grove you need to be within 10 degrees of straight. I may be off but I think it's 10.