How easy/difficult to travel with 14,300 lb dry fifth wheel?

Our 5th wheel weighs in at just under 18,000 lbs.
We tow it an average of 10,000 miles a year and get an average of 11 mpg while towing. As mentioned, wind can be your enemy with fuel economy.
With duallies, the trailer pulls like a dream. and the truck barely knows its there. with so much rubber on the road, big rigs passing by don't affect us.