We have had a few issues over the last 7 years, all you can do is be prepared as best you can, and keep your sense of humor.
We had a tire blow out on our old trailer on I-84, 100 miles east of Portland, OR. Had a spare, changed it, back on the road in 30 mins.
Lost a wheel bearing on the old trailer outside of Weed, CA. Luckily, we were already at our campsite, so I pulled the hub and took it in to a shop, had the new bearing installed and on the trailer in a couple of hours (BTW, we now carry a spare bearing set and seal.)
On the old trailer the plug fell out of the tow vehicle and rubbed on the ground for several hours. Found a NAPA and replaced it that night at the campground.
On the old truck the wheels got out of alignment and wore down one of the front tires. Had to have an alignment kit installed ($800) and new tires ($200 each), this was down by Lone Pine, CA.
With new truck and trailer we had the truck go into "limp" mode due to DEF saturated. This was half-way between Roswell and Albuquerque (hint, there is nothing half-way between Roswell and Albuquerque, not even cell phone service) Limped along for 60 miles at 20mph until we came across a convenience store. Pulled in, called roadside assistance, unhooked the trailer. Tow truck came up from Roswell and took the truck and me (wife stayed in the trailer) back to Roswell. I stayed in a hotel and they "fixed" the truck in the morning. All they could really do was force a manual DEF cleaning, nothing else found wrong. Went to pick up the trailer, when I got there I found that we had picked up a nail in a trailer tire and it was flat. Changed tire with spare, got new tire in Albuquerque. Later on in same trip, picked up a nail in one of the truck tires, near Moab. Put on spare and got it fixed in Moab.
A year later on HW50 half-way between Austin and Ely, NV (there is nothing halfway between Austin and Ely, NV) Truck threw the dreaded DEF saturated error. This time I quickly downshifted to 4th gear and kept driving to make sure I did not go into "limp" mode again.
Moral of the story: Carry lots of tools, always have good spare tires, it is better to be handy than handsome, when you encounter and overcome issues it gives you good stories to tell.
