As a person who has owned all of the big 3 I am going to take a different tack on answering your question as you have not provided extensive information.
When it comes to diesels Dodge has the most bulletproof system, then Ford and then GM. GM is making headway, but has not got all the quirks worked out yet. As for gasoline powered vehicles there is no one vehicle that stands out above the rest. Each has its strong performers and its lemons.
Really what it is going to boil down to is what pleases you. For example, I have found that the seats in GM vehicles for the past 20 years are very uncomfortable to sit on so I stay away from GM for that reason and go with Dodge or Ford.
There are your diehards like my BIL who will only own a Dodge and my son who will only own a Ford. Me? I drive each every time I go looking and usually end up with the same conclusion Dodge or Ford for comfort reasons and purchase from which ever dealership gives me the biggest discount on the vehicle I desire. And I will shop every dealership in a 100 mile direction, and I have had prices vary as high as $1500 on the same truck (Ford to Ford & Dodge to Dodge)
