I agree that there are a number of ways that weight can be reduced with the use of some of the new materials. However, in the RV world, I think big parts of the additional weight come from items for which a real quality substitute has not been found yet.
8000#lb axels are bigger and heavier--differences in frames make probably one of the biggest differences in weights. The box frames tend to be much heavier than most of the I beams, and even here a heavier gauge steel will add weight over a lighter grade.
Some materials don't make as much difference in weight as one might suspect. For example, Excel uses a wood frame rather than aluminum. I was surprised to find out that the use of the wood only adds about 300# over what aluminum would weigh.