Ram 2500 with 6.4 Hemi for 5th wheel

MRE I pull the trailer in my signature with a 5.7 Hemi and 3.73 gears. I cant see why you would have struggles with the 6.4 but would depend on the rear end. I don't think twice about taking ours most anywhere although just a little higher gear would be better (3.90's) W have pulled ours over 25000 miles on trips from home to Albequerque, down I-75 and I-77 (W. Va. turnpike) to Florida. You will get a lot of different ideas by the weight police but make your own decision. Good Luck and Happy Camping.