We're brand new to RV'g, 5th Wheel and TH ! so not not sure my uninformed opinion would count for much.....but what little I've learned in getting ready over the last year and 1/2 for our next adventure....
We considered a 5er BH for the extra sleeping, but the TH;s all seemed to have greater Cargo capacity, greater tankage and almost universally come with the Onan genset as a standard. That plus having the flexibility of using the garage for various purposes rather than dedicated bunkhouse finally swayed us.
My TV is a (new to me) 2013 F450 that we flew down to Chicago to pickup and drove back up the hwy last fall. Awesome truck, unbelievable turning radius, 24k towing and 14k GVW. I picked up a 24ft enclosed for my son while we were down there and averaged 12.8 mpg (ok it was empty) for the 4k return trip. With no regard to trying to maximize mileage (often cruising at 70+ where safely able)
that's my 2 cents..........