There is a lengthy article in Trailer Life, June 2013 page 50. It explains the difference between ST verses LT tires, and how they can have an effect on your trailers handling. ST tires contain chemical compounds to resist weather and ozone cracking. Your tandem or triple axle trailers put a tremendous amount of side load on the tires when turning, as ST tires have stiffer sidewalls that LT tires. Did you know that ST tires are designed to run at a max speed of 65 MPH? ( Unless Stated Otherwise) Plus higher speeds result a build up of heat in the tire, that have a direct impact on it's lifespan.
Different tire MFG recommend a different life expectancy from there tires. Carlisle states that one third of the tires strength is gone after 3 years, thus they recommend replacement of tires regardless of tread depth. Other tire MFG are in the range of 7 to 8 years. I for one go by the 6 year rule. The end of the article states, follow the RV, MFG guidelines as to your tire size and choice, LT or ST.