Generally I only stayed at one location about 2-3 days when I had my toy hauler. 5 days was about the max, but I always left camp to go sight seeing or riding my motorcycle when I had it along. With that in mind, It would get cumbersome setting up and tearing down all the time. For the most part, I'm outside when I'm at camp anyway, and if the weather is bad I'm inside, and I wouldn't want the water or cold infiltrating through the patio room.
To top that off, once it comes time to pack up and leave, I don't want to spend more time than necessary gearing up to leave. What that means is the more stuff I have set up, the longer it takes to put all that stuff away.