I went from 17" to 18", but my originals were 265/70-17 and I went to 275/70-18, and it was on a Ford. Brand doesn't matter, but point is you are starting out smaller than mine. (just saw your edit on size - so you would be making the same size jump as I did)
On the positive side, you get a higher load rating, a tire that fills the wheel house better (looks) and more ground clearance.
On the negative side, you might have bed height issues under your fiver. Wheels - I found take-off OEM 18" wheels, which are hub centric. If you go with aftermarket wheels, I don't think there are any that are hub centric. They are all lug centric. Even though they are rated for the weight, I would hate running lug centric wheels under heavy loads. Fuel mileage - it will probably suffer a little bit. Power - it will suffer a little bit, but the CTD has plenty to spare. Tires will cost more. Not as good a selection in 18".
The pro list is shorter than the con list, but I'm happy that I did it. The added load capacity alone is worth it to me.