I have a 2017 Jayco 5th wheel. Before departing the campground I open the black water valve, drain the tank then use the internal tank flush for 15 - 20 minutes. I then close the black and grey water ...
Could be the bottom of the tanks are sagging and driving down the road sloshes the fluid enough that it goes down the pipe. I know for a fact this has always happened with ours and I suspect it's very common.