Can’t leave the gun at home when you are full-time RVing and the RV is your home. I have never once heard a person say that they drove thousands of miles and only had one or two incidents where they needed a gun, or they have been RVing for 30+ years and only needed a gun a few times; it is always how long they have been doing something and never needed a gun.
The thing is you only need one incident, only one, and it does not matter how long you have been traveling on the road; that one incident can mean the difference between life and death. After I got out of the army my first job was as an ambulance paramedic (EMT) and I saw lots of murders, suicides, vehicle accidents, etc. It only has to happen once and the difference could depend on whether or not you can defend yourself.