Really great responses so far...thanks so much!
You only live once. If your wife wants to try full timing do it. Spend time on the forums, blogs, and webpages and there are a lot of them about full timing so you can be ahead of the learning curve in some ways. Take it one day at a time. If the kids live other places, go visit them in the RV. Stay in their driveways. Use the RV to do the things you do not or cannot do when stuck in a stick and brick home. Nobody says you must do it forever, but enjoy each day because we never know how many more we have. Someday way out in the future your wife will talk about and remember the full timing days far more than the stay at home days.