I also have a 5.9 275 cummins ISB in my '99 endeavor. I have been wondering the same thing.
I ran into a gentleman at a gas station a few months ago that had a 5.9 cummins in his truck and swore up and down you could put a programmer into an RV with the same engine. He called it a smarty JR and said it cost about $500.
He also said that the engine would go from a 275 hp to a 325 hp(or more) with just adding the programmer. Not sure if this is true, but might be worth buying if it actually works.