They should not drop all the way to the replace mark with a clean filter. If they do, then something else is going on - like the FM has failed. I think the problem is that the heat or vibration gets to them. what ever the case, they do seem to fail regularly.
The FM gives an excellent indication of when it's clogged to FleetGuards own specs. Like I said, I checked it to the air filters specs with a Mightyvac and it was right-on.
OTOH, if one has done anything to increase the boost an eng makes, the FM will be pulled down even sooner. On my own Cummins, I went from 26 PSI to 37 PSI and I draw a clean filter down to 20%. I'm just over powering it.