We travel from SE GA to SW NJ (about 810 miles) 4 to 6 times a year, 2 with the motorhome, the rest in the car. I generally drive the entire trip in one shot. Depending on which vehicle we are driving, how many stops we have to make (meals and potty breaks) and how much traffic there is, it takes us anywhere from 11.5 hours to 15 hours. By myself with no meal breaks, one gas stop (5 - 10 max) and one potty break (5 min max), I usually do it in about 11.5 hours with no traffic.
How tired I am at the end of the day depends on when we leave. With the car, we generally leave around 3:00 am and get there around 3 pm. I am usually fine for another 5 - 7 hours. In the motorhome, we usually leave 9 am and get there around 11 pm. I'm usually tired, but not exhausted. I'll be in bed by midnight or so.
Our motorhome handles great. No white knuckle driving for me. I am also in my early 40's and I enjoy traffic free driving. The most miles driving the Motorhome in one shot was 900 miles.
-Michael