Best route from Branson, Mo to Biloxi, Ms any ideas?

I drive this all the time. If you don't mind hills in Arkansas The best route is take US 65 South to Conway from Springfiled, MO, (No Hills after Conway) then I40/US 65 to Little Rock, In Little Rock, take US 65 South to Lake Village, ARK. You want to stay straight at Lake Village onto US 82 and cross the MS River going towards Greenville, MS. Take the first Right onto MS 454 after crossing the Bridge. This will dead end (approx 7 miles) into MS 1. (Left turn will take you into Greenville and you can gas up and eat before heading south to Vicksburg) Turn right onto MS 1 South and you will follow it until it ends at MS 14. Turn Left and go approx 5 miles. You will see a sign (cant remember the road) to Vicksburg, MS (Right Turn) follow this till it dead ends into US HWY 61 South (maybe 3 miles). Going straight will take you into Rolling Fork and you will hit US 61 South from there. Follow 61 to Vicksburg, MS (approx 45 miles). From there you have 2 options. Take I-20 East to Jackson, MS until you hit US 49 South and proceed to Biloxi. or cross over the interstate and take MS 27 south until you hit MS 28 at Georgetown, MS. Turn Left on 28 until you hit US 49 and follow 49 to Biloxi.

If you want to expressway all the way, head south from KC to Fort Smith, ARK, then I-40 to Little Rock. Then see above or continue to Memphis, TN, then I-240/55 South and follow I55 South to Jackson, MS. From there pick up US 49 South to Hattiesburg, MS and then to Biloxi.

The best way to get around Hattiesburg if you don't want to go through town is to take I-59 South towards New Orleans for a few miles and get off on US 98 towards Mobile. You will follow this for a few miles and it will hit US 49 on the South Side of Hattiesburg. Easy Drive. Good Luck. I live in Vicksburg and have run up and down this road for years. Just Remember when you drive in the Delta, it is a little drive between gas pumps.