Not a current owner, but here are my two centavos:
I like the Ford E-350/E-450 chassis. It isn't the cheapest, nor is it the latest tech. It guzzles fuel (6-10MPG for a typical class "C" compared to 18-20 MPG for a Sprinter V6.) However, it has been around so long that almost all the bugs are gone, and it works extremely well. The V-10 is hard to kill, and if I do destroy it, $5000 + labor gets me a new one from a crate. Its electronics don't go haywire if you look at it wrong, and if it does die, there are many, many Ford places that can fix those.
It is an extremely modifiable engine. If I want a turbo so I don't have as much power loss on grades, that is doable. In fact, there is a local mechanic shop that has done many supercharger upgrades on E-350-E-450 based class "C"s (just so the rig doesn't lose steam in Colorado, Oregon, or other places), and the breakage rate is quite low. One thing I will get, should I get a class "C", is a second alternator/voltage regulator, so I have 200-280 amps right to the house batteries, allowing me to run the roof A/C while on the road, or have A/C in areas where generator operation is banned.
The cost difference between an E-350/E-450 and a Sprinter can buy a ton of fuel.
Of course, this is just my opinion, and other people's have things equally as valid. Take it for what you will...
