An out of balance tire/wheel certainly will have varying amounts of vibration at various speeds; it will be worse at the resonant frequency or frequencies of the suspension system. A slightly out-of-balance tire on my car will be smooth at 50 mph, cause noticeable vibrations between around 60-65 mph, and be smooth again at around 75 mph or so. Obviously the exact speeds vary between different vehicles.
It's also possible on a motorhome especially for the drive shaft to be out of balance, which causes vibrations at different speeds than tires would.
The front-end alignment spec of importance here is caster, which you want to be at the upper end of the allowable range (maybe four degrees or so). Having properly inflated tires for the weight and making sure there is sufficient weight on the front axle are quite important, too.
You would likely have gotten more in depth and perhaps quicker answers by posting in the class C forum. There are some quite knowledgeable people there, and they may not all look in this forum.