I-75 would be my choice. Take I-75 South to Florida’s Turnpike South (exit 328, old 65), to I-4 West (exit 259) to Walt Disney World Exits. I would leave Saturday.
We like Holiday Travel Park in Chattanooga TN (Rossville GA) about 6 hours from Dayton with no stops.
We stop in Lake Park GA at Eagles Roost or there is a remodeled campground Good Sam at Camping World across the highway. Lower rates. Good for overnight. There is a Flying J at Lake Park also. Lake Park is about 5 hours from Chattanooga with no stops.
Then get on Florida Turnpike at Wildwood (toll). $10.11 for 4 axles. I would stop and get a SunPass transponder and set up an account. Mini transponder $4.99. You can purchase one via vending machine at:
Hamilton County Welcome Center
Interstate I-75
Mile Marker 470
1.7 mi. S of FL/GA state line
Jennings, FL 32053
Enjoy your trip!