A 10,000-pound increase in GVW or GCW will increase fuel consumption by about 8.5% (0.55 MPG) and is equivalent to a loss of 80 engine horsepower at 45 MPH (8 HP / 1,000 lb @ 45 MPH) on a 6% grade.
Some facts to consider:
• Proper tire inflation pressure is important for your safety and that of others. Maintaining correct inflation pressure based on the actual tire load will also optimize tire life, vehicle ride quality, and fuel economy. With a tire pressure 10 psi lower than the manufacturer’s recommendation for the weight, fuel economy will drop 0.5%.
• All tires are least fuel-efficient when new. As the new tire wears, the rolling resistance decreases and fuel economy improves.
• Most of the fuel economy advantage is obtained when the tread is 50% worn.
From:
Motor Home Fuel Economy