In "the old days" there was a contention that "piston miles" was an engine life factor. An engine in a pickup with a 3.25 rear end vs a MH with a 4.56 rear end had a substantially different rpm at 60 mph. The theory was that the MH engine would have a shorter mileage life as a result of the "piston miles" This theory had some merit when big block engines of the 80's and 90's were in use. Few of those engines would reach 100k miles without major work.
The V-10 is an entirely different technology. My 2000 Class A traveled at 26,000 pounds CGVW for 127k miles before I had to pull the heads due to a "spit plug". No visible, or measurable wear on the valves or cams. Did have the valves polished while the heads were off, and new stainless inserts in all plug holes to correct the V-10 design flaw of only 3-4 threads of aluminum catching the plug. The compression was at new levels after the heads were reinstalled. I used Amsoil, then Mobile 1, tested the oil at 7500 mile intervals and testing would indicate need to change at 35-35k miles.
The "house" part of a V-10 equipped MH will need everything replaced long before the drive train becomes an issue (except for the tranny). 200-300k miles will not be a problem in a moderately maintained V-10 in a MH.