i used to maintain a fleet of E350. I would get 500,000-600,000 miles out of them. Ford had problem with their COPs from 98-2004 I would change them all and be done with it. Changing plugs is not the horror story these guys a portraying. I never sprayed any lube done the hole. Never a problem. I would use compressed air to blow out the hole after the coil is removed. You would be surprised what dust and dirt comes out that you do not want to fall down into cylinder when plug is removed.
Also magnetic spark plug socket that comes attached to a long extension is your best friend for doing plugs. Can be had at auto zone for $12
JKaz