I worked for a shuttle bus company in Portland OR. They had several of the E-350 vans with 5.4L V8 above 350,000 miles and one at 410,000 that was for sale, but still driven daily, putting on about 200 - 250 miles per shift 2 shifts per day.
Motors tend to last a LOT longer than in the 60's and 70's when at 75,000 miles you where looking for a new car. The current cars must pass the emissions standards at 100,000 miles without a problem, so they have to be built more robust than in years past. It is not uncommon for a car or truck engine to last well into the 250,000 mile range without rebuilding today.
That said, the RV is loading up the engine a lot more than a pickup truck would. They are well known to last to 100,000 miles in RV service too. My hesitation in buying a older unit with 100,000 miles is not the transmission or engine, but the steering box, suspension, and other things starting to show signs of wear, and less attentive to tracking straight down the road after all that wear and tear. The box might show signs of strain from all that rattling down the road, ect.
Good luck on your RV search!
Fred.