I have a Class C on the E-450 Chassis with the big V-8 engine. I have a towing capacity of 7500 pounds. That’s enough to pull a one ton full size truck! But I can assure you I won’t be doing that. I do tow a 2019 Ford Ranger and it works just fine. If you get a bigger and heavier Class C you may lose some of that towing capacity. You’ll also have less capacity with the E-350 chassis. It should tow the Colorado okay. I think when I was looking the same configuration Colorado was about 900 pound heavier than my Ranger. Ford use the Aluminum body on the ranger which makes it much lighter for towing.