Itasca Spirit 24V on Ford 350 Chassis

I have an '03 24V on the E-450 chassis. I tow a Jeep Cherokee all over the West and it has adequate power for this. The E-350 has a slightly taller rear axle ratio which will give it a little less pulling power and maybe a little better gas mileage. I've gotten an average of 8.5 mpg towing my Cherokee for about the last 30,000 miles. It's hard to get a better average mpg without driving 50 mph. It's easy to get lower mpg by driving 70 with a lead foot. Mine rides pretty rough in the rear because it's rather over-sprung for the load carried. An E-350 will be less harsh. One of the main things to look for is water damage. If the caulking has not been maintained and the unit is parked out in the weather all year, it's pretty easy to have water damage issues.