The engine and transmission are unlikely to fail for a very long time, especially given most motorhomes in personal use gain comparatively little mileage. The Ford drivetrain generally could be expected to go at least a quarter million miles with reasonable maintenance and without major problems, and indeed does so frequently in work vans, shuttle busses, etc. That's not to say that there aren't parts that wear out or comparatively minor problems that may need taking care of. In general, the house part of an RV will wear out well before the chassis.
Most everything I've seen from people who have ex-rental units from Cruise America has been positive, and most negative comments I see come from people who would, by their own admission, never consider purchasing one. I certainly would be willing to buy one (and particularly the 19G, which doesn't have many or any comparable models available elsewhere) if the layout met my needs and I could afford it at the time.
