Are you going to tow? If yes get the V-10 Ford {or the 6.0L Chevy}, it is just that simple. Yes, the Sprinter/MB "can" tow but they do not do it very well. I've passed many laboring up a 6 per cent grade with their flashers on. Look closely at the CCC or OCCC {whatever they are quoting these days}. The Sprinter chassis will not even come close to the payload of an E-350/450.
The Sprinters get better mileage, no question {think 15 - 17 and no, they do NOT get 20+} but it's not that much better given the seriously higher maintenance costs that come with a MB diesel not to mention the higher cost of diesel fuel in most locations. Expect around 9 - 10 {8- 9 towing} mpg with a V -10.
Any little town big enough to have a Dollar Store probably has a Ford dealer who can work on your V-10 - authorized MB dealers are spread pretty thin. If you doubt it go on line and check for authorized MB service centers.
Yep, I have an E-350 V-10 {full disclosre here}.
As always.... Opinions and YMMV.
:C
