We (both turning 60 next year) have an E350 with a 6-way power driver seat that the RV manufacture supplied. The seat can be adjusted all the way back without interference to the dinette behind it. I am 5'-11" and 190 pounds. I have one complaint regarding driver comfort. That is the position of the gas and brake pedal relative to the driver seat.
When I have been away from the motor home for months at a time, every time I first get in the driver seat and hit the brake pedal to put the vehicle into gear, I mistakenly press the pas pedal. The two pedals are skewed to the left because the engine compartment is so wide. Studying my relative position as I am used to with all my other vehicles, the gas pedal is where the brake pedal should be, and the brake pedal is where a clutch pedal would be if I had one. My seat is in the correct position relative to the steering wheel so the seat is mounted properly. After a day or two of discomfort from it, I adjust to the skewed pedals and all is okay for the balance of the trip.
When my wife drives, I sit in the passenger position and am comfortable with the limited leg room. In that seat, we both sometimes rest our right stocking foot on the dash to the right of the air bag, and other times place our left leg between seats.
I think we would all agree that E350/E450 leg room is tight, but neither my wife and find it to be an issue. It really is no matter at all for us, driver or passenger positions. Either discomfort is blown out of proportion, or the people with exceptional discomfort have issues with arthritis and leg/hip joints.
