We've put about 30,000 miles on the RV, all without a toad. We didn't have a suitable vehicle to tow when we got the motorhome, so we decided to go toadless for awhile and see how it worked. Worked out fine, mostly with Enterprise, sometimes with Avis, local trips my wife would drive one of our cars.
We've had a few aggravations (sometimes late)with Enterprise, but they always picked us up and were always polite and helpful. Now, we did plan our trips and reserve cars in advance. We'd sometimes pick a campground with Enterprise access, then use their car to get to the distant attraction we wanted to visit (did I mention always unlimited mileage?)
Obviously, you have to allow time to pick up and drop off a car, so it can't be as convenient as jumping into your own car. On the other hand, we don't have to sweat getting into or out of a tight gas station.
Since our motorhome usage has ranged from 10 weeks/year to 2 weeks/year, it costs a lot less to rent than to buy a new car. If you're fulltiming, then it makes a lot more sense to tow.
Ed