Weigh your rig and set pressures to Toyo's chart plus a few psi _or_ set it to stated max psi of the tire or rim. There is no other answer and just randomly lowering pressure for a better ride is idiocy. Underinflated tires blow out. Remember the Ford Explorer blowouts and rollovers?
I use Toyo 8R19.5 tires and weigh 20,000lbs. By Toyo's (and others) chart I need to run 105 psi on the front and 110 psi on the rear. Oddly, stickers on the rig indicate 95 psi, which is underinflated for the stated max weight of the rig. It's not a smooth ride but it's a safe ride.