Gjac, I had a problem getting the plastic plug out of the water heater the first time I winterized it (had to cut and pick it out). Been using a little Never-Seize since.
I also found a slight leak on one of the radiator hoses when changing oil. It was caused by a cracked spring clamp (one of Ford's not so good ideas).
Due to issues with the older V10's blowing out spark plugs, I very carefully changed the plugs at 40,000 miles. See
http://www.rv.net/forum/index.cfm/fuseaction/thread/tid/26856381/gotomsg/26876259.cfm#26876259 for details.
I did forget one other flat tire that I had due to a flexible valve stem extender failing. Fortunately, it probably happened on a couple of miles of washboard road leading to a place I camped for several days. The tire was flat when we got ready to leave. Replaced the normal valve extenders with one that won't let the air out of the tire if it fails.
I have changed the tranny fluid to Mobil 1 synthetic and use Mobil 1 in the engine.
I also replaced the brake pads and brake fluid at 40,000 miles.