Swapping Dash Board & Door Panels, Older To Newer E350/E450

I believe its doable. I've seen pics of it done once.

Both years use CAN-BUS networks, so the wiring should be the same. You will have to have the new instrument cluster programmed to work with your PCM, as they go through a VIN check at startup. That step will require a shop with a Ford IDS terminal. Or, if you buy a new cluster of from a certified rebuilder, they can preprogram the VIN (and mileage).