We've tried both ways and still when I go long distance we'll do the trailer (4up) and if we are going less than a tank of fuel we will tow 4 down.
We've had to disconnect the jeep several times because were caught in a place where we were required to back out. I can back the trailer.
Plus, with the jeep up, I do not worry about all the stuff that would be spinning if it were 4 down. With the jeep I still have two differentials and a transfer case spinning. With the trailer it's only 4 tires
IOWs it really depends where we are going, what we will do when we are there. It's nice to know we will have a place to park the trailer.
4 down or 4 up it really makes no difference how the coach feels or drives.