The biggest factor to wind is the type of coach you are driving. My first coach was an underpowered DP on a Freightliner chassis and 19" wheels and weighed about 19,000. It really did not handle well at all with a cross-wind. We left FL with 30-40MPH winds and only made it 3 hours before I was completely exhausted. This coach is a bus conversion weighing in at about 40,000 (plus towed) and was built for over the road driving. We were in some Santa Ana winds at 60+MPH and dead cross-wind. If I had known better, I would never have driven but I did not understand the power of that kind of wind at the time. I made the hour drive safely but I would never recommend anyone attempt that in any RV. The winds were actually lifting the trailers ahead of us off the ground! Had one gone over, it's hard to tell how badly things might have gone as there was also nearly zero visibility due to the blowing sand.
Just use some common sense and don't drive if you don't need to.