colliehauler wrote:
I gave Bud Sentinel the 6th and he did not have a seizure until the 14th. He had his shots on the 6th as well. Last month he had his Sentinel on the 1st and had his seizure the 10th. He has been on Sentinel for years, I stop during winter......
Collies have problems with crossing the brain barrier and well "known problems" with Sentinel.Here is just a bit of info.
It has to do with a mutation in Collies and the research is ongoing to identify the mutation.
Collies can not tolerate the
Milbemycin oxim and it
crosses the brain barrier if they have the mutation.
Sentinel Flavor Tabs ... Each tablet is formulated to provide a minimum of 0.23 mg/pound (0.5 mg/kg) of milbemycin oxime
......
A rising-dose safety study conducted in rough-coated collies manifested a clinical reaction consisting of ataxia, pyrexia and periodic recumbency in one of fourteen dogs treated with
milbemycin oxime...Milbemycin oxim..
.......So-called "ivermectin" sensitivity is actually sensitivity to a broad class of compounds due to a basic defect in the blood-brain barrier.
http://www.bordercollie.org/boards/index.php?showtopic=4966......
Collie owners have long known that ivermectin in the treatment of helminths and mites can result in death of some Collies. Until the mutation and its frequency were discovered, the inconsistency in toxic reaction within the breed caused some confusion. Now we know that approximately 30% of collies are homozygous for the mutation, and these are the Collies particularly at risk. Because a commercial test is now available, purebred Collies should be genetically tested before administering any drug that is a P-glycoprotein substrate in high doses
Sensitivity of Collies to certain pharmaceuticals,
in particular for treatment of heartworm and mites (ivermectin), is now known to be caused by a genetic defect in the mechanism that prevents drugs from building up in the brain.
This mutation is recessive and is called mdr1-1?. The normal gene that protects the brain is called MDR1.
A test for this mutation is now commercially available.
Research shows that 1 in 3 or 4 Collies in the U.S. is "pure" for the mutation. These Collies suffer acute and often fatal neurotoxicosis when certain drugs are administered at
high doses in treatment and prevention of heartworm, and this may also apply to other ailments (see below).
. http://www.awca.net/drug.htm ==THIS is the best link for information on Collies.
.....
Studies have shown that the Collie breed and other herding dog breeds may be more sensitive to elevated levels of Milbemycin and more likely to have adverse reactions including coma and death. If you are concerned, discuss the safety of Milbemycin with your veterinarian. Some forms of Milbemycin are flavored with pork extracts and may cause a food allergy in sensitive pets.
http://www.petmd.com/pet-medication/sentinelIt might just be the Sentinel. The vets should have known about not giving those to a Collie breed, and it's been my experience they ALWAYS want to dose on the UP side of what the dogs weight is. Which in the case of a Collie would be real serious and could be the cause of his seizures.
I'll get you a phone number of an AKC Collie breeder that can help you.