Our Henry is an older longer hair cat with hyperthyroid disease and is very prone to losing hair :B. It's not a huge problem, but we vacuum daily.
He's mostly great when we move, and always great when we're stationary.
I've had cat patients that just wouldn't adapt to vehicles even with sedation, anti-nausea medication, and OTC medications/pheromone efforts. I'm convinced there are a few individuals that wouldn't adapt, but they are the exception rather than the rule.
Doug, DVM