We've taken every cat with us every time we used the car for anything, shopping etc. No cage, no meds and not allowed in the front. Took a month for them to settle down then they just sleep while moving including the motorhome. Every cat the same. Always use a short red leash to know where they are in case they get out or time to move the slide outs. Does a cat every sleep?
Read an interesting story. Cats can't see up close, so when catching prey or a toy their whiskers move straight forward to detect the prey. They also use hairs on their ankles. It's sub second speed that you can't see but captured on high speed video.