We've used mostly Frontline on our Shepherd mix. Last year we tried Advantix a couple times, but both times within a minute after application he got nervous, panting and pacing for a couple hours. Doesn't have any problem with the Frontline.
Have found a few dead ticks on the floor. Occasional tick crawling on him after a walk. Only a couple actually attached to him - not sure how long they would have stuck on him before the Frontline would take effect - none have been at all engorged.
Have found more on myself than the dog this year.