Our 2 cats travel in the largest dog kennel I could fit in the back seat of my pickup, with a shelf I built into it for more room. At first, they fussed and meowed the whole time, but now they meow for a bit and calm down and sleep. We do take frequent stops to allow them to use the litter box in the trailer. We just allow a little more time for the trip. We have thought about a motorhome and if that would be easier with the kittys, having the ability to wander around while traveling, But they are probably safer in a kennel, in your truck or a motorhome.