Check out the import requirements for South Africa and for return to the US. You need to plan way ahead of time and go through the international requirements and many require prior authorization. Titers for many diseases have to be performed before your trip.
In this time I'd also be concerned about COVID and medical care available in South Africa. I know that their health care system is NOT third world caliber and if they are not overwhelmed with COVID should provide the type of care available here in the states.
USDA APHIS web site.