The only system that provides almost no distraction while driving, is a voice guidance with pre-planned route that you've already loaded into your device.
You can use a mouse without taking eyes off the road, but you need to take eyes off the road to see WHERE you are moving that mouse.
About Copilot - I used it in free smartphone version and wasn't too thrilled. Besides, it let me down by disabling the most needed feature - voice guidance. Nowhere in the description it said that the free version was voiceless, there even was a test of voice, like in a real thing - only it didn't work on the road. Instead, it displayed a message suggesting to buy their paid version - very nice, when you're on the road without data connection :)