It can get pretty lonely if you are out traveling alone from place to place and changing every 3-4 days.
Is there a firm reason why you and your wife won't be going together; does she just not want to be in a camper? or does she just not want to be with you?
You asked about a MH or a TT. A 5 yr old MH will cost you about 70K, but a 5 yr old TT will cost you less than 10K. It all depends on how much you want to expend to follow your dream. I would also suggest you check out fifth wheels since you get a little more luxury, plus they are more open and provide better full-time living than MOST travel trailers.
You will have to have an extra vehicle, most likely a pickup truck if you choose a TT or 5'er or a smaller vehicle if you choose a motorhome.
To purchase a new residence to stay in, check out AARP's best places to live. They compare cost of living to availability of services, activities, etc.