I think that most folks that full-time are happier with a decent size fifth wheel or motorhome due to storage space, both outside compartments and inside closets, cabinets, etc. However, your truck is your "daily driver" so you have to factor in it's gas mileage when not towing. There are some bigger class C units that could feasibly work for full timing if you can handle traveling somewhat lighter than most because they usually don't have as much storeage capacity and possibly weight capacity to avoid maxing out the GVWR. But, with a class C, you could tow a smaller and more fuel efficient vehicle for driving when not towing. I going with a long travel trailer (over 30'), I'd want a diesel truck that could provide a traveling range of over 350 miles on a full tank of fuel to prevent having to navigate fuel stops that can be tricky to navigate with a long travel trailer and larger truck.