You can fly and rent an RV but that will be expensive. Also, by the time you figure departing 3hr before the flight, 2hr flying & 2hr to collect bags and pick up the rental...you've already got the equivalent time to 500 miles driving...in the end, your 4 day trip is really a 2 day trip when you remove the travel days.
It rarely takes 2 hours to pick up bags and a rental. In 2.5 hours of flight time from Boston I can be in Florida. If I drive and I am REALLY lucky in those 9 hours you talk about I might be able to make it to Washington, DC, IF there is no traffic. I am also much more rested and relaxed when I fly as I can sleep on the plane and possibly even salvage 1/2 day on either travel day depending on where I am headed.
