It really boils down to what you are willing to put up with when it comes to a tow vehicle.
Any truck capable of towing a larger sized 5th wheel or toy hauler 5th wheel will be less comfortable as a daily driver. I have used a 3500 dually crewcab long bed and now have a 4500 dually crewcab long bed and was willing to put up with poor ride quality to have a safer towing experience.
For more comfort a 2500/F250 will be a little better and you can still get a fairly large TT, 5th wheel or toyhauler.
A suburban or expedition provides a better ride along with the capability to tow a good sized TT or toyhauler.
Here's a rule of thumb to keep in mind. Most RV'ers go through 3 RVs before they buy one that really fits their needs. Typically start off small with a Camper, tent trailer or small TT. Move up to a bigger TT or small MH. Then move into the 32ft Plus sized RV. It may be better to start off big.