I would rent a MH and take it on at least a one week trip of 1000 plus miles.
Get a feel for it. To get the feel for towing a trailer you can rent trucks and trailers from a few sources, but your best bet is a friend or a relative that may have one and let you drive it while they instruct you.
We prefer a 5th wheel but I think a MH would be a better choice for someone that has never towed or backed in a trailer.
You do get more for your money with a 5th wheel- dollar for dollar. But once you add in the new truck the cost is very close to a mid-level MH.
To answer the MH long drives vs 5th wheel long stay it boils down to two reasons:
To go from the tow vehicle to the 5th wheel you have to get out in the weather, unlock the entrance door and get in the 5th wheel.
With a MH you pull over and take a step back to the living area. No weather concerns.
The other reason, before leveling jacks were added to 5th wheels it took longer to get settled in a camp site. MH would be setup in less than a half hour. 5th wheels would take up to an hour. Now that time difference has gone away due to the auto levelers on 5th wheels.